Applies only to oral form of both agents. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Individual plans may vary A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. . In the text below the tool there is more information on how the iron deficit is calculated. Chandler G, Harchowel J, Macdougall I. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. If we don't have the calculator you need then tell us the details and we'll make it for you. Applies only to oral form of both agents. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Applies only to oral form of both agents. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. It can be expressed in mg per ml. Administer on 5 different occasions over a 14 day period. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. It is unlikely . In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Deferasirox chelates iron. Avoid or Use Alternate Drug. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Schweiz Med Wochenschr; 100(7):301-3. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Avoid or Use Alternate Drug. Applies only to oral form of both agents. 1970;100(7):301303. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Venofer [package insert]. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Applies only to oral form of both agents. Minor (1)iron sucrose, benazepril. Use Caution/Monitor. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Comparable efficacy to that of IV iron sucrose. https://www.uptodate.com/ (Requires subscription). 4. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Compare formulary status to other drugs in the same class. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Drug Des Devel Ther; 5: 5160. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. If you log out, you will be required to enter your username and password the next time you visit. Use Caution/Monitor. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Applies only to oral form of both agents. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Applies only to oral form of both agents. Use Caution/Monitor. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Venofer is given as an infusion into a vein. 2. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Use Caution/Monitor. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Applies only to oral form of both agents. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Dosing: (a) Divide calculated total cumulate dose . Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Applies only to oral form of both agents. Administer Venofer only intravenously by slow injection or by infusion. Use Caution/Monitor. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Modify Therapy/Monitor Closely. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Applies only to oral form of both agents. Do not mix iron sucrose with other medications or TPN solution. Objective. informational and educational purposes only. Applies only to oral form of both agents. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. For liquid medications, also enter the value of the Medicine Concentration and choose . Treatment of anemia due to iron deficiency. Use Caution/Monitor. Schweiz Med Wochenschr. Applies only to oral form of both agents. Applies only to oral form of both agents. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Written by ASHP. Applies only to oral form of both agents. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Either increases effects of the other by pharmacodynamic synergism. *Administer early during the dialysis session. Applies only to oral form of both agents. Adding plans allows you to compare formulary status to other drugs in the same class. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Modify Therapy/Monitor Closely. Official Journal of the International Society of Nephrology. Parenteral iron dextran therapy: a review. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown. Manage and view all your plans together even plans in different states. LBW = Lean body weight in kg. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. 2010;18(3). Feraheme does not contain antimicrobial preservatives. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Administer while the patient is in a reclined or semi-reclined position. Contact the applicable plan -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Separate dosing of tetracyclines from these products. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Before using, check this product visually for particles or discoloration. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Applies only to oral form of both agents. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. 3. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Avoid or Use Alternate Drug. Human studies not conducted. The dosage of Venofer is expressed in mg of elemental iron. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Slow or stop the infusion if adverse reactions occur. David McAuley, Pharm.D. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Minor/Significance Unknown. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Total dose iron infusion: safety and efficacy in predialysis patients. 2.1 . Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Use Caution/Monitor. Use Caution/Monitor. 1. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. 1 ,*. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Applies only to oral form of both agents. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. J Lab Clin Med. Avoid or Use Alternate Drug. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Many patients with kidney disease cannot get enough iron from food and require injections. Deferoxamine chelates iron. Applies only to oral form of both agents. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Minor/Significance Unknown. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Modify Therapy/Monitor Closely. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Parenteral iron dextran therapy. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. If either is present, do not use the liquid. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Calculates iron deficit for dosing iron. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Last updated on Jun 1, 2022. There are physiological variation in iron reserves such as the decrease during menstruation period. Ferritin and transferrin are also recommended monitoring . Applies only to oral form of both agents. Minor/Significance Unknown. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Schweiz Med Wochenschr; 100(7):301-3. Deferasirox chelates iron. Your doctor will do laboratory tests to monitor your response. 1988 May;111(5):566-70. Either decreases levels of the other by inhibition of GI absorption. Avoid or Use Alternate Drug. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. This cost includes the fee charged by the pharmacy. Our dosage calculator can help you with this as well. This website also contains material copyrighted by 3rd parties. Your doctor will do laboratory tests to monitor your response. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Shirley, NY: American Regent, Inc.; 9/2020. Do not double the dose to catch up. Use alternatives if available. Intravenous iron-dextran: therapeutic and experimental possibilities. Separate by at least 4 hours. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. If we don't have the calculator you need we'll try to make it for you and add it to the website. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. A: Generally acceptable. This information does not assure that this product is safe, effective, or appropriate for you. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Minor/Significance Unknown. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it.
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